The Kindlin 2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FERMT2. This antibody recognizes Human, Mouse, and Rat antigen. The Kindlin 2 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Function: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Subunit Structure: Interacts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1.
Similarity: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3, 4, 5-trisphosphate, and has lower affinity for phosphatidylinositol-4, 5-bisphosphate (PubMed:22030399).The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues. Belongs to the kindlin family